Positive regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Positive regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABI2, ZNF280C, and WASF1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Arp2/3 complex-mediated actin nucleation activity versus ABI2 in LARGE_INTESTINE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ABI2 →	+1.348	+0.148	<.001	<.001	3	15
OVARY	ZNF280C →	+0.733	+0.088	.007	.004	3	14
BONE	WASF1 →	+2.534	+0.177	<.001	<.001	3	13
BONE	RSF1 →	+0.926	+0.170	.001	.005	2	14
BLOOD_Leukemia	FCHSD2 →	+1.116	+0.150	<.001	<.001	3	12
LUNG_NSCLC_LUAD	TTL →	+1.019	+0.093	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000601 vs ABI2 — LARGE_INTESTINE

Explore this scatter interactively →