Positive regulation of Arp2/3 complex-mediated actin nucleation

Across TCGA cell cohorts, RNA activity of the Positive regulation of Arp2/3 complex-mediated actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSKH1, SEPTIN1, and PPP1CC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Arp2/3 complex-mediated actin nucleation activity versus PSKH1 in LUNG_NSCLC_LUSC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PSKH1 →	+1.130	+0.302	<.001	<.001	3	5
BLOOD_Lymphoma	SEPTIN1 →	+3.815	+1.452	<.001	<.001	3	5
LARGE_INTESTINE	PPP1CC →	+0.460	+1.070	<.001	<.001	3	5
LIVER	MDH1 →	+0.840	+0.219	.003	.002	3	4
BLOOD_Lymphoma	SSBP2 →	+2.927	+1.365	<.001	<.001	3	4
BLOOD_Lymphoma	PPP2R3B →	+2.240	+1.139	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000601 vs PSKH1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →