Regulation of platelet-derived growth factor receptor-beta signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS2, RCN3, and VCAN_S2116, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-beta signaling pathway activity versus THBS2 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THBS2 →	+1.394	+0.098	<.001	<.001	3	8
BRCA	RCN3 →	+0.678	+0.098	<.001	<.001	3	7
OV	VCAN_S2116 →	+0.898	+0.105	.001	<.001	3	7
OV	C1R →	+0.559	+0.071	<.001	<.001	3	7
OV	C1S →	+0.581	+0.085	<.001	<.001	3	7
COAD	CCN1 →	+0.779	+0.062	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000586 vs THBS2 — OV

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