Regulation of platelet-derived growth factor receptor-beta signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSN, CHI3L1, and LGALS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-beta signaling pathway activity versus MSN in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSN →	+0.557	+0.169	.004	<.001	3	5
LSCC	CHI3L1 →	+0.849	+0.162	.004	.003	3	5
LSCC	LGALS1 →	+0.668	+0.128	<.001	<.001	3	4
LSCC	SUDS3 →	-0.528	-0.212	<.001	<.001	3	4
LUAD	GPR84 →	+0.663	+0.160	.002	.001	2	5
LUAD	NFKBIE →	+0.334	+0.155	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000586 vs MSN — LSCC

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