Regulation of platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOO, APCDD1L, and MCAT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENOO grouped by Regulation of platelet-derived growth factor receptor-beta signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SELENOO →	+1.004	+1.501	.003	.003	3	6
LUNG_NSCLC_LUSC	APCDD1L →	-2.079	-1.185	.005	.008	3	5
BLOOD_Myeloma	MCAT →	+1.233	+1.229	.002	.003	3	5
LUNG_SCLC	HYI →	-1.531	-1.012	<.001	.005	3	5
LUNG_NSCLC_LUSC	NR1I3 →	+0.685	+1.607	.009	.007	3	4
LARGE_INTESTINE	IFI27L2 →	-1.514	-1.297	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENOO by Regulation of platelet-derived growth factor receptor-beta signaling pathway activity — BLOOD_Myeloma

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