Regulation of platelet-derived growth factor receptor-beta signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of platelet-derived growth factor receptor-beta signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP1, HIP1R, and HIP1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet-derived growth factor receptor-beta signaling pathway activity versus LRP1 in URINARY_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LRP1 →	+2.406	+0.266	<.001	<.001	3	13
BLOOD_Lymphoma	HIP1R →	+2.018	+0.111	<.001	<.001	3	12
SOFT_TISSUE	HIP1 →	+1.490	+0.150	<.001	.001	3	11
OVARY	LMBR1L →	+0.873	+0.137	<.001	<.001	3	9
CNS	ZNF117 →	+1.570	+0.118	<.001	.001	3	9
BREAST	GAL3ST4 →	+0.819	+0.091	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000586 vs LRP1 — URINARY_TRACT

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