"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAPBP, IDO1, and IFIH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity versus TAPBP in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TAPBP →	+0.462	+0.590	<.001	<.001	3	6
HNSC	IDO1 →	+1.886	+0.994	<.001	<.001	3	5
HNSC	IFIH1 →	+0.958	+0.779	<.001	.001	3	5
HNSC	PARP9 →	+0.679	+0.767	.001	.002	3	5
BRCA	TAP1 →	+0.848	+0.598	<.001	<.001	3	5
BRCA	LINC02100 →	+0.657	+0.518	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000562 vs TAPBP — BRCA

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