"Negative regulation of CD4-positive, alpha-beta T cell proliferation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD4-positive, alpha-beta T cell proliferation" pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM120A, DNAAF4-CCPG1, and EHD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM120A grouped by "Negative regulation of CD4-positive, alpha-beta T cell proliferation"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FAM120A →	-0.213	-0.174	.008	.001	3	3
BREAST	DNAAF4-CCPG1 →	+0.151	+0.746	.009	.006	3	3
BLOOD_Myeloma	EHD1 →	-0.260	-1.681	<.001	<.001	3	3
URINARY_TRACT	GCSHP3 →	-0.294	-0.369	<.001	<.001	3	3
LIVER	CIDEA →	-0.193	-1.939	.006	<.001	3	3
LIVER	ZDHHC11 →	+0.253	+1.939	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM120A by "Negative regulation of CD4-positive, alpha-beta T cell proliferation" activity — KIDNEY

Explore this box plot interactively →