"Positive regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH3B1, AHR, and FOSL2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD4-positive, alpha-beta T cell activation" activity versus ALDH3B1 in BONE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ALDH3B1 →	+2.378	+0.109	<.001	.001	3	13
SOFT_TISSUE	AHR →	+2.074	+0.116	.001	<.001	3	12
BONE	FOSL2 →	+3.444	+0.150	<.001	<.001	3	12
BONE	TGFBR2 →	+2.668	+0.147	.003	<.001	3	11
BLOOD_Leukemia	PLXNB2 →	+2.080	+0.057	<.001	.007	3	11
STOMACH	ZFP36 →	+1.489	+0.089	.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000516 vs ALDH3B1 — BONE

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