"Regulation of CD4-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF6B, GOLGA6L10, and WDR31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATF6B grouped by "Regulation of CD4-positive, alpha-beta T cell activation"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ATF6B →	-0.738	-1.081	.001	.001	3	4
BLOOD_Leukemia	GOLGA6L10 →	-1.256	-1.304	<.001	<.001	3	4
BONE	WDR31 →	-1.010	-1.462	.005	.001	3	4
BLOOD_Lymphoma	OIP5 →	+1.132	+1.396	.005	.004	3	3
OESOPHAGUS	HID1 →	-1.603	-0.756	.009	.008	2	4
SOFT_TISSUE	KRT10 →	-1.214	-0.976	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATF6B by "Regulation of CD4-positive, alpha-beta T cell activation" activity — STOMACH

Explore this box plot interactively →