Positive regulation of hepatic stellate cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of hepatic stellate cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORBS1, MDM2, and MED11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SORBS1 grouped by Positive regulation of hepatic stellate cell activation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SORBS1 →	+0.225	+0.149	.007	<.001	3	5
SOFT_TISSUE	MDM2 →	+0.428	+0.215	<.001	<.001	3	5
CNS	MED11 →	-0.568	-0.230	.007	.008	3	4
SOFT_TISSUE	TP53 →	-0.742	-0.266	<.001	<.001	3	4
SOFT_TISSUE	CDKN1A →	-0.378	-0.234	<.001	.002	3	3
SKIN	MMD →	+0.223	+0.203	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SORBS1 by Positive regulation of hepatic stellate cell activation activity — BLOOD_Leukemia

Explore this box plot interactively →