Regulation of cAMP-dependent protein kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of cAMP-dependent protein kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKAR2B, TBC1D24, and ADD1_S481, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cAMP-dependent protein kinase activity activity versus PRKAR2B in OV (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKAR2B →	+0.738	+0.042	<.001	.009	3	6
GBM	TBC1D24 →	+0.291	+0.057	<.001	<.001	3	5
GBM	ADD1_S481 →	+0.663	+0.073	<.001	<.001	3	5
HNSC	PANK4 →	+0.232	+0.067	<.001	<.001	3	5
HNSC	PKIA →	+0.876	+0.052	<.001	<.001	3	5
OV	PHLDB1_S470 →	+0.784	+0.049	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000479 vs PRKAR2B — OV

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