Regulation of cAMP-dependent protein kinase activity

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cAMP-dependent protein kinase activity pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of cAMP-dependent protein kinase activity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and BRCA, show the opposite pattern, with higher activity associated with better survival.

UVM, BRCA, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.818	0.422	<.001	109	view →
BRCA	OS	Tertile	III,IV	0.752	0.505	.001	43	view →
ESCA	OS	Tertile	All	0.696	0.476	.009	38	view →
HNSC	DFS	Quartile	IV	0.571	0.183	<.001	37	view →
KIRC	DFS	Quartile	IV	0.184	0.469	.009	34	view →
KICH	OS	Median	II,III,IV	0.520	1.000	.008	31	view →
DLBC	DFS	Quartile	All	0.292	1.000	.018	20	view →
LGG	DFS	Median	All	0.806	0.667	.005	20	view →
ACC	DFS	Tertile	All	0.302	0.681	.014	11	view →
TGCT	DFS	Quartile	All	0.563	0.873	.011	10	view →
LUSC	OS	Median	IV	0.255	0.851	.021	6	view →
READ	OS	Tertile	III,IV	0.925	0.598	.028	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:2000479–UVM (OS)

Open the UVM breakdown →