Regulation of cAMP-dependent protein kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of cAMP-dependent protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS3P4, NKPD1, and MAP1LC3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cAMP-dependent protein kinase activity activity versus PRSS3P4 in PDAC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRSS3P4 →	-0.429	-0.131	.007	.006	3	4
HNSC	NKPD1 →	-0.421	-0.208	.004	.009	3	3
OV	MAP1LC3B →	+0.476	+0.153	.005	.007	2	4
COAD	MAPRE3 →	+0.516	+0.263	<.001	.001	3	3
HNSC	CORO1C →	-0.335	-0.363	.003	.001	3	3
HNSC	EFHD1 →	+0.863	+0.274	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000479 vs PRSS3P4 — PDAC

Explore this scatter interactively →