Regulation of cAMP-dependent protein kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of cAMP-dependent protein kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP1, PVR, and PTPRB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQGAP1 grouped by Regulation of cAMP-dependent protein kinase activity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IQGAP1 →	-1.137	-1.966	.002	<.001	2	6
SOFT_TISSUE	PVR →	-1.218	-1.291	.002	.001	3	5
CNS	PTPRB →	-1.417	-1.256	.004	<.001	3	5
BONE	DNMT3A →	+2.481	+1.946	.002	<.001	3	5
OVARY	ITPR2 →	-1.058	-1.616	.002	<.001	3	5
LARGE_INTESTINE	FOSL1 →	-1.385	-0.810	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQGAP1 by Regulation of cAMP-dependent protein kinase activity activity — BONE

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