Regulation of cAMP-dependent protein kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of cAMP-dependent protein kinase activity pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are TWS119 and Pyrimethamine, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TWS119 grouped by Regulation of cAMP-dependent protein kinase activity-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TWS119 →	+0.644	+0.215	.028	.012	2	1
LUNG_SCLC	Pyrimethamine →	+0.820	+0.215	.008	.012	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest associations by consensus.

TWS119 by Regulation of cAMP-dependent protein kinase activity activity — LUNG_SCLC

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