Positive regulation of protein neddylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein neddylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZPR1, CUL5, and RNF214, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein neddylation activity versus ZPR1 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZPR1 →	+0.252	+0.052	.002	.005	3	7
HNSC	CUL5 →	+0.232	+0.059	.001	.004	3	6
LUAD	RNF214 →	+0.166	+0.043	.001	<.001	3	5
LSCC	DCUN1D5 →	+0.340	+0.056	<.001	<.001	3	5
LUAD	ARHGAP26 →	-0.253	-0.034	.004	.004	3	5
BRCA	AASDHPPT →	+0.324	+0.034	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000436 vs ZPR1 — HNSC

Explore this scatter interactively →