Positive regulation of apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2I, NXPE3, and LBHD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2I grouped by Positive regulation of apoptotic cell clearance-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POLR2I →	+0.572	+0.737	<.001	<.001	3	5
URINARY_TRACT	NXPE3 →	+2.072	+1.837	.008	<.001	3	4
LUNG_SCLC	LBHD1 →	+1.048	+1.360	.001	.004	3	4
PANCREAS	EID2B →	+1.628	+1.298	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	BMERB1 →	+1.622	+1.250	<.001	.002	3	4
BREAST	DSTYK →	+0.573	+0.769	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2I by Positive regulation of apoptotic cell clearance activity — BREAST

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