Positive regulation of apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic cell clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENON, SLC38A3, and KCNT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENON grouped by Positive regulation of apoptotic cell clearance-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SELENON →	+0.180	+1.383	.008	.003	3	5
LUNG_NSCLC_LUSC	SLC38A3 →	-0.461	-1.435	<.001	.004	3	4
LUNG_NSCLC_LUAD	KCNT1 →	-0.112	-0.643	<.001	.007	3	4
BLOOD_Leukemia	TBL1Y →	-0.463	-1.222	.007	.007	2	5
BLOOD_Myeloma	AGRP →	-0.209	-0.276	.001	<.001	3	4
BREAST	MOS →	+0.144	+1.030	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENON by Positive regulation of apoptotic cell clearance activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →