Negative regulation of lymphocyte migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of lymphocyte migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASA3, RCOR1, and SMARCA4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte migration activity versus RASA3 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RASA3 →	+0.621	+0.041	.001	.002	3	8
HNSC	RCOR1 →	-0.245	-0.074	.003	.002	3	7
BRCA	SMARCA4 →	-0.248	-0.046	<.001	<.001	3	7
LSCC	TOP2A_S1525 →	-1.033	-0.078	.002	<.001	3	7
LSCC	CHAF1A_S141 →	-0.632	-0.069	<.001	<.001	3	7
BRCA	MAPRE2 →	+0.429	+0.036	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000402 vs RASA3 — OV

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