Positive regulation of lamellipodium morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of lamellipodium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1C, FOSL1, and AIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lamellipodium morphogenesis activity versus CORO1C in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CORO1C →	+1.100	+0.815	<.001	.001	3	5
LUNG_NSCLC_LUAD	FOSL1 →	+2.869	+0.682	<.001	<.001	3	5
BONE	AIP →	+1.663	+0.501	<.001	<.001	3	5
SKIN	PHLDA1 →	+1.349	+0.610	<.001	.006	3	4
LUNG_NSCLC_LUAD	DUSP16 →	-0.676	-0.510	.006	.001	3	4
LUNG_NSCLC_LUAD	SMIM29 →	+0.796	+0.450	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000394 vs CORO1C — LUNG_NSCLC_LUAD

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