Regulation of lamellipodium morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of lamellipodium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLXDC2, GSN, and PRKG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium morphogenesis activity versus PLXDC2 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLXDC2 →	+0.507	+0.071	<.001	.001	3	8
UCEC	GSN →	+0.531	+0.085	<.001	<.001	3	8
UCEC	PRKG1 →	+0.690	+0.094	.002	.002	3	8
OV	PUS7 →	-0.327	-0.062	.006	.004	3	8
LSCC	CHAF1A_S141 →	-0.929	-0.085	<.001	<.001	3	7
LSCC	DAB2 →	+0.506	+0.082	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000392 vs PLXDC2 — OV

Explore this scatter interactively →