Negative regulation of endothelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA5A, APOA4, and PDPK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA5A grouped by Negative regulation of endothelial cell apoptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEMA5A →	-0.254	-1.015	.002	<.001	3	7
LUNG_SCLC	APOA4 →	-0.228	-1.009	<.001	.003	3	6
BREAST	PDPK1 →	-0.321	-0.736	.001	.003	3	6
URINARY_TRACT	GATA3 →	-0.421	-1.520	.004	<.001	3	5
SOFT_TISSUE	ACP1 →	+0.210	+1.303	.009	.002	3	4
UPPER_AERODIGESTIVE_TRACT	GAS6 →	-0.185	-1.266	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA5A by Negative regulation of endothelial cell apoptotic process activity — BREAST

Explore this box plot interactively →