Negative regulation of endothelial cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CANT1, LPAR5, and SGTB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CANT1 grouped by Negative regulation of endothelial cell apoptotic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CANT1 →	-0.985	-0.694	.003	.008	3	4
STOMACH	LPAR5 →	-1.466	-0.731	.007	.005	3	4
STOMACH	SGTB →	+1.505	+1.235	.004	.002	3	4
STOMACH	LLGL2 →	-2.265	-0.755	.001	.003	3	4
LUNG_NSCLC_LUAD	KLF16 →	-0.727	-1.167	.002	<.001	3	4
LARGE_INTESTINE	GALNT4 →	-1.457	-0.985	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CANT1 by Negative regulation of endothelial cell apoptotic process activity — STOMACH

Explore this box plot interactively →