Positive regulation of acrosome reaction

Across TCGA patient cohorts, RNA activity of the Positive regulation of acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLB1, CACNA1H, and CCDC87, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of acrosome reaction activity versus PLB1 in MESO (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	PLB1 →	+1.345	+0.054	<.001	<.001	3	19
LIHC	CACNA1H →	+2.186	+0.065	<.001	<.001	3	19
BRCA	CCDC87 →	+0.622	+0.041	<.001	<.001	3	16
MESO	PLCB1 →	+0.918	+0.058	.001	<.001	3	16
SCLC	ZP3 →	+1.255	+1.047	<.001	<.001	3	15
LIHC	FAM234A →	+0.535	+0.040	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000344 vs PLB1 — MESO

Explore this scatter interactively →