Positive regulation of chemokine (C-X-C motif) ligand 2 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemokine (C-X-C motif) ligand 2 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD4, FAM78A, and FOLR2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemokine (C-X-C motif) ligand 2 production activity versus CD4 in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD4 →	+0.852	+0.390	.001	<.001	3	7
GBM	FAM78A →	+0.705	+0.465	<.001	<.001	3	7
GBM	FOLR2 →	+1.318	+0.414	<.001	.001	3	7
GBM	GNGT2 →	+0.637	+0.553	<.001	<.001	3	7
GBM	CD28 →	+0.556	+0.294	.002	.004	3	7
GBM	SPN →	+0.780	+0.522	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000343 vs CD4 — GBM

Explore this scatter interactively →