Regulation of T-helper 17 cell lineage commitment

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 17 cell lineage commitment pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, ACTN1, and SERPINE1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 17 cell lineage commitment activity versus LGALS1 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LGALS1 →	+4.605	+0.775	<.001	.004	3	11
BLOOD_Lymphoma	ACTN1 →	+2.593	+0.360	.003	.009	3	7
LARGE_INTESTINE	SERPINE1 →	+1.992	+0.412	.002	.003	3	7
BONE	UPP1 →	+2.852	+0.183	.003	<.001	3	6
BONE	MBNL3 →	-1.765	-0.204	.004	<.001	3	6
BONE	GFPT2 →	+3.190	+0.198	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000328 vs LGALS1 — LARGE_INTESTINE

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