Regulation of glucocorticoid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of glucocorticoid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNP, TRAJ44, and DISP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucocorticoid receptor signaling pathway activity versus CNP in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CNP →	-0.311	-0.174	<.001	<.001	3	4
BRCA	TRAJ44 →	-0.524	-0.232	.001	<.001	3	4
COAD	DISP1 →	+0.405	+0.281	.002	<.001	3	3
LUAD	SLC38A7 →	-0.313	-0.139	.001	.005	3	3
LSCC	NLRC5 →	-0.536	-0.150	.002	<.001	3	3
LSCC	C8orf89 →	+0.166	+0.112	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000322 vs CNP — LUAD

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