Regulation of glucocorticoid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of glucocorticoid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUV39H1, ATP10D, and ETS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUV39H1 grouped by Regulation of glucocorticoid receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SUV39H1 →	+0.689	+0.822	.001	.003	3	5
BONE	ATP10D →	+0.970	+0.276	.008	.002	3	4
BLOOD_Myeloma	ETS2 →	+1.853	+1.090	.005	.002	3	3
BLOOD_Myeloma	OXCT2 →	-1.103	-1.108	.001	.002	3	3
LUNG_NSCLC_LUAD	CCDC6 →	+0.394	+0.520	.005	.008	3	3
LUNG_NSCLC_LUAD	DTL →	+0.523	+0.670	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUV39H1 by Regulation of glucocorticoid receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →