Regulation of T-helper 17 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 17 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP3, KIAA0232, and DUSP28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP3 grouped by Regulation of T-helper 17 cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LTBP3 →	-1.231	-1.024	.007	.005	3	4
PANCREAS	KIAA0232 →	-0.567	-0.952	.004	<.001	3	3
PANCREAS	DUSP28 →	-0.663	-1.062	<.001	.001	3	3
PANCREAS	PSME1 →	+0.682	+1.049	.002	.002	3	3
URINARY_TRACT	CLCN7 →	-1.650	-1.845	.006	<.001	2	4
BONE	WASF1 →	-1.614	-1.308	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP3 by Regulation of T-helper 17 cell differentiation activity — KIDNEY

Explore this box plot interactively →