Negative regulation of T-helper 17 type immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 17 type immune response pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNA3, IL3RA, and TRAV9-2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 17 type immune response activity versus KCNA3 in PDAC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KCNA3 →	-0.530	-0.190	.004	.005	3	5
LSCC	IL3RA →	-0.268	-0.135	.009	.003	3	4
LSCC	TRAV9-2 →	-0.468	-0.128	.001	.006	3	4
HNSC	TRAJ43 →	-1.540	-0.189	<.001	.002	3	4
BRCA	TLR10 →	-0.531	-0.174	.009	.003	3	4
BRCA	TBC1D10C →	-0.527	-0.148	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000317 vs KCNA3 — PDAC

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