Regulation of NMDA receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of NMDA receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPT, HIRA, and TRAV26-2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NMDA receptor activity activity versus GAPT in LSCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GAPT →	+0.667	+0.518	<.001	<.001	3	5
LSCC	HIRA →	-0.293	-0.444	<.001	.003	3	5
GBM	TRAV26-2 →	+0.303	+0.498	.003	.003	3	5
LSCC	BTLA →	+0.732	+0.700	<.001	<.001	3	5
LSCC	RBM28 →	-0.401	-0.518	<.001	.006	3	4
LSCC	MCM7 →	-0.622	-0.474	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000310 vs GAPT — LSCC

Explore this scatter interactively →