Regulation of myoblast proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of myoblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF3C2_S167, FGA, and SERPINB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast proliferation activity versus GTF3C2_S167 in LSCC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF3C2_S167 →	-0.372	-0.056	<.001	<.001	3	5
OV	FGA →	+0.755	+0.060	.003	.007	3	4
BRCA	SERPINB2 →	+0.818	+0.037	.003	.005	3	4
LSCC	RPGR_S518 →	-0.506	-0.064	<.001	<.001	3	4
PDAC	DCUN1D3 →	+0.320	+0.051	.007	.006	2	5
OV	RPGR_S961 →	-0.508	-0.052	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000291 vs GTF3C2_S167 — LSCC

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