Regulation of myoblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNMT, HSPA8, and TM4SF19, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNMT grouped by Regulation of myoblast proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RNMT →	+0.095	+0.737	.005	.007	2	2
LUNG_NSCLC_LUAD	HSPA8 →	+0.438	+0.737	.008	.007	2	2
LUNG_NSCLC_LUAD	TM4SF19 →	+0.200	+0.737	<.001	.007	2	2
LUNG_SCLC	MORN4 →	-0.160	-0.396	.009	.005	2	2
LUNG_SCLC	CSMD1 →	-0.400	-0.396	.008	.005	2	2
OESOPHAGUS	HSD17B2 →	+0.186	+0.464	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNMT by Regulation of myoblast proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →