Regulation of myoblast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4A2, ERN1, and SERPINE1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast proliferation activity versus EIF4A2 in LARGE_INTESTINE (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF4A2 →	-0.760	-0.569	.005	.002	3	2
LARGE_INTESTINE	ERN1 →	-0.953	-0.651	.002	.004	3	2
LUNG_SCLC	SERPINE1 →	-1.110	-0.350	.008	.007	2	2
LUNG_SCLC	HIVEP2 →	-2.630	-0.396	.005	.005	2	2
LUNG_SCLC	SNX4 →	+1.264	+0.396	.004	.005	2	2
LUNG_SCLC	BTBD11 →	+4.915	+0.396	.004	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000291 vs EIF4A2 — LARGE_INTESTINE

Explore this scatter interactively →