Positive regulation of fibroblast apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF879, GGPS1, and SLC6A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF879 grouped by Positive regulation of fibroblast apoptotic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF879 →	+0.729	+1.799	<.001	<.001	3	4
STOMACH	GGPS1 →	-0.699	-0.959	<.001	.004	3	4
PANCREAS	SLC6A6 →	-1.158	-1.038	.003	.006	3	4
LUNG_NSCLC_LUSC	UBE2R2 →	-0.813	-1.418	.001	.001	3	4
URINARY_TRACT	FA2H →	+1.520	+1.861	.003	.002	3	3
BLOOD_Leukemia	RAB32 →	-3.080	-1.017	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF879 by Positive regulation of fibroblast apoptotic process activity — URINARY_TRACT

Explore this box plot interactively →