Positive regulation of fibroblast apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK17B, BTG1, and STK17A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast apoptotic process activity versus STK17B in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STK17B →	+1.479	+0.142	<.001	<.001	3	9
SOFT_TISSUE	BTG1 →	+1.632	+0.530	<.001	<.001	3	7
BREAST	STK17A →	+1.516	+0.129	<.001	.003	1	9
SOFT_TISSUE	PAFAH1B3 →	-1.134	-0.555	<.001	.006	3	6
SOFT_TISSUE	CACNA1H →	-1.153	-0.438	.003	.004	3	6
UPPER_AERODIGESTIVE_TRACT	DUSP3 →	-0.558	-0.055	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000271 vs STK17B — BLOOD_Lymphoma

Explore this scatter interactively →