Regulation of fibroblast apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of fibroblast apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHO2, EPB41L3, and ANKRD44, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast apoptotic process activity versus PLEKHO2 in COAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLEKHO2 →	+0.332	+0.026	<.001	<.001	3	8
HNSC	EPB41L3 →	+0.467	+0.078	<.001	.001	3	7
HNSC	ANKRD44 →	+0.417	+0.083	<.001	<.001	3	7
BRCA	WAS →	+0.380	+0.046	.002	<.001	3	7
BRCA	PRKCB →	+0.552	+0.046	.002	<.001	3	7
UCEC	THEMIS2_T593 →	+0.912	+0.084	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000269 vs PLEKHO2 — COAD

Explore this scatter interactively →