Regulation of fibroblast apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of fibroblast apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1958, WDR47, and MIR3907, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast apoptotic process activity versus KIAA1958 in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIAA1958 →	-0.460	-0.693	.002	.001	3	3
CCRCC	WDR47 →	+0.251	+0.561	.005	.006	3	3
OV	MIR3907 →	+0.864	+0.211	.004	.001	3	3
PDAC	PLA2G12A →	-0.248	-0.668	.001	.002	3	3
PDAC	CCDC42 →	+0.062	+0.734	.004	<.001	3	3
PDAC	IFFO2 →	+0.309	+0.474	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000269 vs KIAA1958 — CCRCC

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