Regulation of fibroblast apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD8, TP53, and RPL22, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHD8 grouped by Regulation of fibroblast apoptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CHD8 →	-0.355	-0.747	.001	.004	2	13
OVARY	TP53 →	-0.954	-1.735	<.001	<.001	3	11
SOFT_TISSUE	RPL22 →	-0.339	-1.631	<.001	<.001	3	7
SKIN	PRSS23 →	+0.307	+1.079	<.001	.002	3	7
SKIN	MDM2 →	+0.660	+1.001	<.001	<.001	3	6
SKIN	SLC4A3 →	-0.281	-1.141	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHD8 by Regulation of fibroblast apoptotic process activity — BREAST

Explore this box plot interactively →