Positive regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Positive regulation of feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGIP1, DKK3, and RASGRF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of feeding behavior activity versus SGIP1 in CCRCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SGIP1 →	+0.900	+0.478	<.001	<.001	3	5
LSCC	DKK3 →	+0.791	+0.318	.001	<.001	3	4
GBM	RASGRF2 →	+1.034	+1.263	<.001	<.001	3	4
GBM	AMOTL2 →	+0.856	+1.081	<.001	<.001	3	4
LUAD	BMP4 →	+1.306	+0.406	<.001	.001	3	4
LSCC	CLEC11A →	+0.506	+0.257	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000253 vs SGIP1 — CCRCC

Explore this scatter interactively →