Negative regulation of feeding behavior

Across TCGA patient cohorts, RNA activity of the Negative regulation of feeding behavior pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISG20, EFHD2, and EAF2_S154, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of feeding behavior activity versus ISG20 in BRCA (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ISG20 →	-0.531	-0.074	<.001	<.001	3	6
BRCA	EFHD2 →	-0.441	-0.096	<.001	<.001	3	5
COAD	EAF2_S154 →	-0.443	-0.120	.006	.005	3	4
OV	NHSL2_S339 →	-1.163	-0.144	<.001	.002	3	4
PDAC	PATL1_S278 →	-0.645	-0.115	<.001	.001	3	4
HNSC	BLZF1 →	-0.245	-0.117	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000252 vs ISG20 — BRCA

Explore this scatter interactively →