Negative regulation of feeding behavior

Across TCGA cell cohorts, RNA activity of the Negative regulation of feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD8, PLAGL2, and ZBTB10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTBD8 grouped by Negative regulation of feeding behavior-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BTBD8 →	+0.863	+1.531	<.001	.006	3	4
LARGE_INTESTINE	PLAGL2 →	+0.626	+0.859	.003	.001	3	4
PANCREAS	ZBTB10 →	+1.066	+1.249	.001	.006	3	4
LUNG_SCLC	BRD3 →	+1.408	+0.404	.001	.003	3	4
LUNG_SCLC	HAUS3 →	+1.046	+0.445	.002	.001	3	4
CNS	H3C3 →	-0.715	-1.084	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTBD8 by Negative regulation of feeding behavior activity — BONE

Explore this box plot interactively →