Positive regulation of reproductive process

Across TCGA patient cohorts, RNA activity of the Positive regulation of reproductive process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1, GBP5, and WARS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of reproductive process activity versus SAMSN1 in HNSC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMSN1 →	-0.321	-0.029	.001	<.001	3	7
HNSC	GBP5 →	-0.641	-0.023	.003	.006	3	6
HNSC	WARS1 →	-0.739	-0.030	<.001	<.001	3	6
COAD	SAMSN1_S23 →	-0.648	-0.034	<.001	<.001	3	5
HNSC	SEPTIN1 →	-0.626	-0.027	<.001	<.001	3	5
COAD	STAT1 →	-0.572	-0.024	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000243 vs SAMSN1 — HNSC

Explore this scatter interactively →