Positive regulation of reproductive process

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of reproductive process pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 86 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Positive regulation of reproductive process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and READ, show the opposite pattern, with higher activity associated with better survival.

MESO, KIRC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.223	0.531	<.001	112	view →
KIRC	OS	Median	All	0.475	0.704	<.001	84	view →
ACC	DFS	Median	All	0.373	0.777	<.001	72	view →
LGG	OS	Median	All	0.706	0.883	<.001	52	view →
LUAD	DFS	Quartile	All	0.542	0.755	<.001	38	view →
LIHC	DFS	Median	All	0.368	0.480	.006	35	view →
STAD	OS	Quartile	All	0.298	0.725	.012	30	view →
ESCA	OS	Quartile	All	0.487	0.794	<.001	30	view →
UCS	DFS	Tertile	All	0.280	0.593	.006	28	view →
SKCM	OS	Median	All	0.287	0.469	.001	26	view →
SARC	DFS	Median	All	0.309	0.584	<.001	23	view →
CHOL	DFS	Median	All	0.113	0.623	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:2000243–MESO (OS)

Open the MESO breakdown →