Positive regulation of reproductive process

Across TCGA patient cohorts, RNA activity of the Positive regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGSF5, COX7A2P1, and PLEKHG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of reproductive process activity versus IGSF5 in OV (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGSF5 →	+0.345	+0.819	<.001	<.001	3	4
COAD	COX7A2P1 →	+0.389	+0.663	.003	.001	3	3
GBM	PLEKHG1 →	+0.819	+0.568	<.001	<.001	3	3
GBM	CCDC184 →	+0.732	+0.516	.002	.005	3	3
GBM	NRSN2-AS1 →	+0.298	+0.342	.003	.007	3	3
LSCC	PPARGC1A →	+0.618	+0.665	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000243 vs IGSF5 — OV

Explore this scatter interactively →