Positive regulation of reproductive process

Across TCGA cell cohorts, RNA activity of the Positive regulation of reproductive process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR47, PKP3, and DDB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR47 grouped by Positive regulation of reproductive process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WDR47 →	-0.198	-0.225	<.001	.001	3	3
BLOOD_Leukemia	PKP3 →	+0.185	+1.416	.006	<.001	3	3
PANCREAS	DDB1 →	-0.239	-0.228	.001	.001	3	3
LUNG_NSCLC_LUSC	TP53RK →	-0.303	-0.124	.002	.002	3	3
LUNG_NSCLC_LUSC	MYADM →	+0.297	+0.091	.001	.003	2	4
LUNG_NSCLC_LUSC	TMEM45A →	+0.306	+0.124	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR47 by Positive regulation of reproductive process activity — LIVER

Explore this box plot interactively →