Negative regulation of reproductive process

Across TCGA patient cohorts, RNA activity of the Negative regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5orf46, ASPA, and SNRPC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of reproductive process activity versus C5orf46 in COAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C5orf46 →	+0.837	+0.377	.007	.008	3	4
GBM	ASPA →	+0.620	+0.174	.006	.002	3	4
GBM	SNRPC →	-0.186	-0.169	.005	.003	3	4
GBM	MKLN1-AS →	+0.334	+0.195	.002	<.001	3	4
COAD	C14orf28 →	+0.251	+0.425	.005	.005	3	3
COAD	LINC01614 →	+1.132	+0.475	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000242 vs C5orf46 — COAD

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