Regulation of reproductive process

Across TCGA patient cohorts, RNA activity of the Regulation of reproductive process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUB1, TOP2A, and CENPE, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reproductive process activity versus BUB1 in ACC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	BUB1 →	+1.628	+0.021	<.001	<.001	3	23
CHOL	TOP2A →	+2.328	+0.030	<.001	.003	3	23
LGG	CENPE →	+1.031	+0.016	<.001	<.001	3	23
MESO	KIF15 →	+1.107	+0.025	<.001	<.001	3	23
COAD	YBX1P6 →	+0.489	+0.007	<.001	<.001	2	23
CHOL	TTK →	+1.739	+0.024	<.001	.005	2	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000241 vs BUB1 — ACC

Explore this scatter interactively →