Regulation of reproductive process

Across TCGA patient cohorts, RNA activity of the Regulation of reproductive process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DLGAP4_T915, SLC27A1, and RIF1_S2348, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of reproductive process activity versus DLGAP4_T915 in LUAD (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DLGAP4_T915 →	+0.693	+0.025	<.001	<.001	3	6
UCEC	SLC27A1 →	-0.283	-0.023	.001	.002	3	5
LUAD	RIF1_S2348 →	+1.331	+0.033	.003	.001	3	5
LUAD	TOP2A_S1377 →	+0.741	+0.022	.001	<.001	3	5
LUAD	BRCA1_S114 →	+0.799	+0.027	<.001	<.001	3	5
LUAD	DNMT1_S714 →	+0.510	+0.023	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000241 vs DLGAP4_T915 — LUAD

Explore this scatter interactively →